As far as sticking the parts together is concerned it isn't rocket science.
However, if you look at the graphic picture there on the first page of what the motherboard looks like when it is assembled, you will see something that makes cooling experts cringe.
The two graphics cards have very little space between them. That will mean it is difficult to get air to the card closest to the processor when the thing gets mounted and shoved in a case.
Ideally, a different board would be nice, one that had more space between the cards. The more space between the cards, the less likely your $500 top video card is to melt.
Being aggressive with cooling assumptions is OK for theoretical builds, but I wouldn't want to do it with my own personal production system.
On that note, I would consider not trusting this build to the Antec 300 Illusion case. I haven't used it, but I do know that I would rather have that build in my case instead of the 300 Illusion case with or without the better board that has more room between the video cards.