Yep, I have it running here with an ASUS A7V and AMD TBird 950MHz with no troubles in a 5.1 analog setup. The only catch with the win2k drivers is that AC3 passthru does not work AFAIK. 3D sound with the included games is superb. Some people claim to have a ton of problems with this card, but my install was straightforward and it doesn't even have problems sharing IRQs with a number of other devices. (ACPI)