Well, it is a demanding feature, just like high textures, or high resolution. If you want to use physX, you will have to turn something else down (like change detail from high to medium).
You would probably be fine @ 1280x1024, but you mentioned that you were thinking about getting a 1080p LCD which would add more stress to your GPU, meaning you would have to turn more settings down in order to still play with PhysX
I was just saying that you would probably be more satisfied with High textures in games with no physx, than med-low textures with physx. Therefore, PhysX wouldn't be a good determining factor