What is the make and model of your mouse?
What mouse software are you using?
I have used Microsoft Intellipoint Optical, Microsoft Comfort Optical 3000 and Comfort 6000. None of them worked in Autocad with Win 7 64. I used the latest Microsoft drivers for each mouse.
I just upgraded to Win 7 Pro, and I was able to program the two buttons using the Windows drivers. I used the same Microsoft drivers as mentioned above.
The problem is Win 7 64. Microsoft knows it, but has not come up with any solution or patches. So what else is new?