How many PCIe x 16 slots do you have? If you only have one slot then it is no. And the MOBO on that Dell There is only the one I have a optiplex 320 and it only had one and mine is a lot older than yours also lets say you have two of them your power supply wouldn't be enough. Sorry to give you bad news. I wish you the best of luck
It will work out okay. The company that I work for has been purchasing that Dell recently and I just want them to buy a few that can support two graphics cards so that we can do split presentations with PowerPoint notes. So I will just have to recommend a similar desktop with two cards that is still comparable in price.