I had a Gtx 295 gaming on a 1920 x 1200 res, and the only problem I had was the "power saver feature." You would have to download riva tuner to get it working at normal speed.
If you don't mind taking a massive hit on performance on Dx11 for just a lil more eye candy, and unless you plan on crossfiring, I would go with the 295. It does use more power, and is loud, very loud, but I use head phones, so it doesn't bother me. You would get better performance.