Really what you need to make sure it supports is the sound formats used. You can check out the Voyetta Turtle Beach site for this. The Santa Cruz does in fact support all of the main stream sound formats. Thus you should be fine. From the reviews that I have read, the Santa Cruz does a better job making sound and thus takes less cpu power. Thus a SB Live would eat up more of your cpu cycles. This is not important if you are running fast current processor (i.e. > 700 MHz). Hope this all helps.
It worked yesterday!