Using Eyefinity, can I run a game using only one of my monitors?

Using Eyefinity, can I run a game using only one of my monitors? (1920x1080 and have desktop on either side)?
I would like to run a non-eyefinity game on one monitor (preferably the middle, but I wouldn't mind using a different one) and have the other monitors view the desktop (so I can open a utility to see my computer performance). Usually when I run a game at 1920x1080 (1080p for one monitor) it will clone the game twice and I see three versions of the game at once. Any help is greatly appreciated.
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More about using eyefinity game monitors
  1. Eyefinity is an option, you can run games on one panel or all of them. Using HydraVision you can have multiple desktops
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