One increasingly common problem is that a newly released CPU may not work in an older motherboard without a BIOS update.
Motherboard manufactures also publish a QVL (Qualified Vendor List) of compatible memory (memory that has been tested to work with that motherboard. That does not mean that other memory will not work. It just means that it was never tested.
Power supplies also need to be appropriately sized.
Builder reviews can also give you a lot of information.
Then there's us. If you have questions, ask. Chances are someone here has built a similar system or can tell you why he didn't.
If you look in Articles on Tom's main page you will see hardware reviews for systems and individual parts as well. Maybe these will help you decide on what parts to choose for your budget or intended uses for your computer. Here is just one example. http://www.tomshardware.com/reviews/overclock-benchmark...
well i have those 2 parts, with MSI p55-cd53 motherboard. my graphics driver is at the most current one.
i have been getting occasional blue screen (which hasnt happened recently) of "driver stuck in infinite loop", which after research, might have been a hardware conflict, since my graphic driver is up to date.