Yeah, i think I will RMA it. I'll do it after I purchase an additional card though, so i can at least use it during the long period of time it is away.
I'll try a reseat as soon as i come home from work, might even rebuild the whole darn thing. Try some of this "Cable Management" :P
The PSU is a CoolerMaster Silent Pro Gold 1000W
The hissing is fairly noticeable when i have the speakers down low, however when i turn them up louder its perfectly fine, so i'll just do that until then
I'll let you know how i go once i've re-assembled everything. Thanks everyone for your input so far, it is very much appreciated.