System advice?

http://pcpartpicker.com/p/6Dy1

Intel i7-3930K $550
Zalman CNPS12X $87 ($15 rebate)
Asus P9X79 $255
Mushkin Enhanced Blackline Frostbyte 16GB (4x4GB) DDR3-1600MHz CAS9 1.5V 993995 $87
Seagate Barracuda 1TB 7200RPM ST1000DM003 $98
Intel 520 Series Cherryville 120GB $165
Asus GeForce GTX 680 2GB $508 ($7 shipping)
Antec Eleven Hundred $100
Windows 7 Home Premium 64bit SP1 OEM $100
Asus DRW-24B1ST/BLK/B/AS $20 ($5 shipping)
Total: $1975

With the following PSU:
NZXT Hale90 750W 80Plus Gold Modular $140
http://www.amazon.com/HALE90-Power-Supply-Modular-HALE9...
The Corsair HX 750 is the same price on Amazon last I checked and there's not much to choose between them at the same price.
Which brings the total to $2115

Which leaves ~$800 to get monitor (which I don't have enough knowledge about to make a recommendation, but you should get a high end model), peripherals (personal choice), other software and maybe even a second GTX 680 straight off the bat, depending on spending a small enough amount.

Here you go:

Case: Corsair Carbide 500R - $139.99
PSU: Seasonic X850 Gold - $199.99
Motherboard: Asus Sabertooth X79 - $319.99
CPU: 3.2GHz Intel Core i7-3930K - $559.99
Cooler: Noctua NH-D14 - $84.99
RAM: 16GB G.Skill Ares 1600MHz 1.5V - $89.99
SSD: 128GB Crucial M4 - $159.99
HD: 2TB Seagate Barracuda Green - $119.99
Optical: LG BD-R Burner - $79.99
Video Card: EVGA Geforce GTX 680 - $499.99
OS: Windows 7 Pro - $139.99
Keyboard: Logitech G110 - $69.99
Mouse: Logitech G500 - $59.99
Monitor: Acer G235HAbd 23'' WideScreen LCD monitor - $139.99

Total: $2,724.89

http://www.guru3d.com/article/geforce-gtx-680-overclock... <----- Overclocking the gtx 680 w/benchmarks




http://www.amazon.com/Corsair-Carbide-Series-Gaming-CC-... $118.98 & this item ships for FREE with Super Saver Shipping
Corsair Carbide Series 500R Mid Tower Gaming Case CC-9011012-WW

http://www.amazon.com/XFX-ATX-850-Power-Supply/dp/B0050... $122.75 & this item ships for FREE with Super Saver Shipping
XFX PRO850W XXX Edition Semi-Modular 80 Plus Silver Certified 850 Watt Active PFC Power Supply

http://www.newegg.com/Product/Product.aspx?Item=N82E168... $249.99
ASRock X79 Extreme6 LGA 2011 Intel X79 SATA 6Gb/s USB 3.0 ATX Intel Motherboard

http://www.newegg.com/Product/Product.aspx?Item=N82E168... $599.99 FREE SHIPPING $30 promotional gift card with purchase, ends 4/11
Intel Core i7-3930K Sandy Bridge-E 3.2GHz (3.8GHz Turbo) LGA 2011 130W Six-Core Desktop Processor BX80619i73930K

http://www.amazon.com/Cooler-Master-Hyper-212-RR-212E-2... $34.64 & this item ships for FREE with Super Saver Shipping
Cooler Master Hyper 212 EVO CPU Cooler (RR-212E-20PK-R2)

Add this fan down below to that CM 212 EVO cpu h/s for a "push - pull" effect to help bring the cpu temps down even more.

http://www.amazon.com/Cooler-Master-BladeMaster-Silent-... $11.99 Free Standard Shipping (3-5 days)
Cooler Master BladeMaster 120mm PWM High Air Flow Silent Case Fan R4-BMBS-20PK-R0

http://www.newegg.com/Product/Product.aspx?Item=N82E168... $249.99 FREE SHIPPING 15% off w/ promo code EMCNFNE46, ends 4/11
G.SKILL Ripjaws Z Series 32GB (4 x 8GB) 240-Pin DDR3 SDRAM DDR3 1600 (PC3 12800) Desktop Memory Model F3-12800CL10Q-32GBZL

http://www.amazon.com/Seagate-ST2000DM001-Barracuda-3-5... $119.99 & this item ships for FREE with Super Saver Shipping
Seagate ST2000DM001 Barracuda 7200RPM 2 TB SATA 6 GB/s NCQ 64 MB Cache 3.5-Inch Internal Bare Drive

http://www.newegg.com/Product/Product.aspx?Item=N82E168... $124.99 FREE SHIPPING
Mushkin Enhanced Chronos MKNSSDCR120GB 2.5" 120GB SATA III MLC Internal Solid State Drive (SSD)

http://www.amazon.com/Asus-24xDVD%C2%B1RW-Serial-Intern... $19.99 & eligible for FREE Super Saver Shipping on orders over $25
Asus 24xDVD±RW Serial ATA Internal OEM Drive DRW-24B1ST (Black)

http://www.newegg.com/Product/Product.aspx?Item=N82E168... $499.99
ASUS GTX680-2GD5 GeForce GTX 680 2GB 256-bit GDDR5 PCI Express 3.0 x16 HDCP Ready SLI Support Video Card

or....

http://www.newegg.com/Product/Product.aspx?Item=N82E168... $499.99
EVGA 02G-P4-2680-KR GeForce GTX 680 2GB 256-bit GDDR5 PCI Express 3.0 x16 HDCP Ready SLI Support Video Card

Total: $2,153.59

http://www.newegg.com/Product/ProductList.aspx?Submit=E... <----- SAMSUNG 2ms Full HD LED BackLight LCD 120Hz 3D Monitors

http://www.asrock.com/mb/overview.asp?Model=X79%20Extre... <----- A better look at that board. Also get the latest bios for that board here.

CPU: Intel Core i7-3930K Sandy Bridge-E Socket 2011 - $600
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

CPU Cooling: Thermaltake Frio Overclocking - $57
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Motherboard: Asrock X79 Extreme7 (I know it's not Asus but Asrock are owned by Asus  , it's a very good motherboard though) - $260
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

RAM: G.Skill Ripjaws Z 16GB (4X4GB) DDR3 1600MHz - $90
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

HDD: Seagate Barracuda 1.5TB 5900RPM SATA 6GB/s 64MB Cache - $100
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

SSD: Intel Series 520 Cherryville 120GB SATA III - $180
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Graphics Card: EVGA GeForce GTX 480 1.5GB GDDR5 X2 - $500
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Operating System: Windows 7 Home Premium - $100
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Optical Drive: Sony Optiarc 24X DVD Burner - $18
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Keyboard + Mouse: Microsoft 2.4GHz 5000 Black Wireless Keyboard and Mouse Bundle - $62
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Monitor: Asus 23" Full 1080p Widescreen LCD Monitor w/ Speakers - $160
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Case: NZXT Phantom 410 Black (Also White or Red (same price)) - $100
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

PSU: OCZ ZX Series 850W 80Plus Gold Modular Power Supply - $170
http://www.newegg.com/Product/Product.aspx?Item=N82E168...

Total came to just under $2400, but this is a fantastic system that will do as you please. I know that the motherboard isn't Asus, but it is still a very good motherboard with the latest technologies. You can also spend $50 on Word from Newegg or buy all of the range for $100 (University edition).