Video card interface is a 2.0 socket able to take a 2.1 plug

You mean PCI-E 2.1 card on a PCI-E 2.0 board/slot? No worries, it should be backward compatible. They are just basically almost the same thing and there is no differences on bandwidth. For your Information PCI-E generations are known to be backward compatible, mostly don't require BIOS update, but some does. PCI-E 2.0 cards can be put on 1.0, 3.0 can be put on 2.1 or 2.0, and sometimes when you put 2.1 to 1.0 or 3.0 to 1.0 you need BIOS updates.
 
Well, there are no PCI-e 2.1 slot in any motherboard; it does not exists. So if there were any issues with sticking a PCI-e 2.1 card in a PCI-e 2.0 slot, then a lot of people would be screwed.

As state, PCI-e 2.1 is just a minor revision to the card. In fact, nVidia didn't even bother updating to PCI-e 2.1. All of their current cards are PCI-e 2.0.