The Bitfenix Prodigy, found here, is a Mini-ITX chassis capable of housing a closed water cooler with a 240mm radiator, such as Corsair's H100, found here, at the cost of a 5.25" device (such as a blu-ray burner)
So, here's my question: would a 240mm radiator be more valuable than having access to a blu-ray drive in terms of overall performance? With the 240mm radiator, higher clocks could be achieved at lower temperatures and an extra sata port would be available for an additional hard drive. But with the Blu-Ray drive and a Corsair H80, like this one here, you could have a well-rounded computer.
Performance vs. Functionality. Which trumps the other in the long run?
If you need BluRay burning capabilities, get the BD-R
If you need cooling, get the H100
Now my opinion: I have the Old Corsair H50 running on an i5-2500k, and though I haven't overclocked it yet, it is running cool as a cucumber (a 24C cucumber that is) and has never got over 48C on Prime testing, so I'd get the burner and the H80 or even the H60 if you aren't going to push the CPU hard on overclocking (which I doubt or would try on a case that small and lacking better airflows).