To be honest, I don't see many problems with performance, unless Shadows are enabled with most games. Skyrim, SWTOR, BF3, MW4, any of these games running Shadows shows a fair drop in performance. With them disabled, I have no major issues, though BF3 still has the occasional issue. Running most games on highest settings I can without noticeable frame rate loss, at 1920 x 1080.
My consideration for upgrading now would be to find something that would be good for the next 2-3 years. My GTX 295 has lasted about that length of time, and has only faced real challenges as of late.
Mostly, I'm putting the feelers out to determine if an upgrade is worth doing now (2 GTX560 TIs in SLI), or waiting for one of the Kepler-series of GPUs that is coming out later this year. I'd be looking at the GTX680 based on the leaked information (have a grain of salt handy).
For reference, my system specs without my GPU are:
i2500k (OCed 4.4 Ghz)
ASRock Extreme4 Z68
16 GB DDR3 1333 Dominator Corsair
256GB Samsung 830 SATA3