If you aren't 70 years old with 2 inches of earwax, yes the you can tell a difference...
Anywho, build looks solid OP. I would personally lower the ram to 8gb to save a little dough tho.
Yea, I was debating on that but I figured since RAM is so cheap now I'd just go for it a really future-proof. Besides, I find myself always doing A LOT of multitasking from gaming, Adobe programs, Microsoft office, internet, etc. so more memory doesn't hurt haha (justifies getting more than 8GB for just gaming purposes)