Whoops. Sorry I forgot to reply. I have two PCIe x16 slots, both are working fine. I ran a diagnostic and confirmed that some of my Intel motherboard features were conflicting with my AMD drivers. I disabled it in my BIOS and that fixed the problem entirely.
My only concern now is that the card isn't performing quite as well as I expected. Maybe I'm a fool to think that nVidia sponsored titles would run much better on newer AMD hardware, but still, it's somewhat underwhelming.
Thanks all for the help. Much appreciated.