Such a huge GPU for your Processor, mobo and resolution lol ! of course you can run it, at medium or even at high but you may get lag when theres many things going. I have a system almost as yours, but my GPU is way less powerfull and my resolution is higher. I can play at medium-high, but the game kills my processor, even overclocked at 3.8ghz
You should OC a little your CPU so the bottlenecking wont be that notorius.