If I get the question right you are asking, what in the hierarchy of graphic cards (GPU) is each slot allowed? Lets say I have x4 slot you want to know if I put lets say a GT 430 in that slot.
You want to know how much bigger like a GTX 550 would that be it and can't go any higher? So if this is your question then the answer it doesn't matter how big the card is.
The x16, x8, x4, means how fast the card will run in those slots. 16 being the fastest. All cards have to be PCIe compatible. If you get a card that is AGP it will not work in the PCIe slots.
There is no bottlenecking in the slots from any card. Where bottlenecking accures is when your CPU can't keep up with your GPU. I hope this has helped and I wish you good luck.