When I open an application, play a video, run a game, or do anything on my computer, I get the worst high pitch sound ever... It's like someone drawing on a chalkboard with a razor every time I open something, or click on a hyperlink. Common sense tells me this is my cpu or gpu. But could my hard drive be at risk? Can I ignore this and blast some music while I play games? Is my cpu going too be dead weight if I do?
google the term "coil whine", it's pretty common. It could be GPU or PSU, so replace one at a time and see where that takes you. Lesser common items would be motherboards, so if replacing your GPU or PSU doesn't do it, that leaves the MB as the prime suspect.
PS: It's very rare that a motherboard will report it's temp in Fahrenheit. More than likely it's Celsius, and that's TOO HOT! It your hitting that temp, you didn't do a good enough job applying the heat sink or thermal compound. Turn off the computer, remove the heat sink, clean off old thermal compound (rubbing alcohol works, 70% or greater is preferred) and re-apply thermal compound. Only use about the size of a pea or uncooked grain of rice, and don't worry about spreading it out. The pressure from the heat sink will be more than enough! Report back once you have done that.