Depends. What are the specs on the rest of your system? How old is the power supply? What's the wattage on the 12v+ rail? Who makes it? Answer those four and we should be able to give you a pretty good answer.
Mainboard : Asus CM1730,CM1830
Chipset : AMD 780
Processor : AMD Athlon II X2 220 @ 2800MHz
Physical Memory : 4096MB (2 x 2048 DDR3-SDRAM )
Video Card : ATI Radeon 3000 Graphics
Hard Disk : Seagate ST31000524AS ATA Device (1000GB)
DVD-Rom Drive : ATAPI DVD A DH24ABS
Monitor Type : Acer Acer S202HL - 20 inches
Network Card : Realtek Semiconductor RTL8168/8111 PCIe Gigabit Ethernet Adapter
Operating System : Windows 7 Home Premium Home Edition Media Center 6.01.7601 Service Pack 1 (64-bit)
DirectX : Version 11.00
Yes it will run. However keep in mind you'll be severly bottlenecked by your CPU. I would say get something like a 5670: http://www.newegg.com/Product/Product.aspx?Item=N82E168... and save the rest. In games like BF3 you'll experience annoying micro-stutter because the CPU can't keep up with the GPU. As one who's been in a situation similar to yours a while back, I can say it's a good idea to keep balance.
That said, you could get the 7750 and use it for later if you want to upgrade. 7750 is a decent card there's no doubt about that.
Probably couldn't do it. That would require 2x4pin CPU connectors (I THINK), of which I bet your board only has 1. Plus that extra 30w pushes you too close to the 300w envelope IMO. Get a new PSU then maybe.