I play D3 on the regular with this Video card. It works pretty well most of the time, though I do have lag occasionally. I have all of my FX settings on the lowest possible and the game still looks gorgeous. I've made it through Normal and am into Hell, and only notice that every once in a while when I am facing enormous mobs and the screen is very cluttered with animations and special attacks do I really have any video lag. The D3 servers apparently experience lag as well, so what I am dealing with may not be Vid Card lag, but actual server lag. If you have 4 G of ram with this card you should be perfectly fine.