I'm assuming you are using some sort of adapter for the Card reader+slim DVD drive?
Own a Prodigy myself and it looks great but I'm not sure how much I'd like it as a HTPC. It seems small but it's actually kinda awkward, you need access to most of the sides so it's going to be really hard to tuck away somewhere. Additionally, you can't put anything on top of it really.
Having said that, I don't know of many small cases that can fit 4HDDs + an SSD and an optical drive so it might be fine for your needs. Love mine, despite it's quirks.