All motherboards with PCI-e 1.0/1.1 can support a PCI-e 2.0 card. There are no compatibility issues.
However, PCI-e 2.1 cards may be a problem in some rare cases. Only way to find out is to try it or find someone with the exact same motherboard and find out if he/she had any success with a PCI-e 2.1 card.