What motherboard do you have thats the important part, CPU is more or less irrelevant when it comes to pcie compatibility. But if its 1.1 or higher you will have no problems, you "Might" see some issues with 1.0 if they did not include an updated bios to iron out the issues of the 2.1 cards (had this happen on an old intel board I was trying to make into an HTPC)