Should be no problems, just...
Check the TV will connect to your chosen graphics card. Most have HDMI connectors, but t's a wonderful world and you never know
If the TV is HDCP compliant, drop a Blu-ray drive into the system rather than a DVD, the extra cost is fairly small these days and it'll give you the godness of hi-def movies.
Remember to sit a reasonabe distance away.
Screen size is not what matters, but resolution, a 1920x1080 display takes the same amount of work from the computer to drive, whether it's 19 or 42 inches in size.