Yes, an AMD E-350/450 based system Can Play
Crysis 2, but I would shudder to try in on any Intel Atom system.
But then, AMD's APU's spend quite a bit of silicon on the IGP, usually to good effect.
Not trying to say they are ideal for gaming, but if you have realistic expectations on quality settings and frame rates, you can actually get quite a few games to run.
Personally, I use my C-60 based netbook for playing all sorts of older games while I am away from home.