well if your taget is 60 fps, you might be able to increase a few setting from mid to high. I think the 6850 still runs great for gaming at 1080p. But my standards aren't exactly the highest. I enjoy playing my games without running them on minimal with smooth game play.
Depends on the IQ anyone willing to see, I turn everything on ultra at any game, my HD 6950 sometimes suffers but I never give up on settings like MSAA or AF which have a great impact on performance, and quality too.