For a system using a single reference design Radeon HD 7850 graphics card AMD specifies a minimum of a 500 Watt or greater system power supply. The power supply should also have a maximum combined +12 Volt continuous current rating of 27 Amps or greater and have at least one 6-pin PCI Express supplementary power connector. Some of the non-reference design Radeon HD 7850 graphics cards require at least two 6-pin PCI Express supplementary power connectors and consume more power.
Total Power Supply Wattage is NOT the crucial factor in power supply selection!!! Sufficient Total Combined Continuous Power/Current Available on the +12V Rail(s) rated at 45°C - 50°C ambient temperature, is the most critical factor.
Overclocking of the CPU and/or GPU(s) will require an additional increase to the maximum combined +12 Volt continuous current ratings, recommended above, to meet the increase in power required for the overclock. The additional amount required will depend on the magnitude of the overclock being attempted.
The Corsair TX Series TX650 (SKU# 75-001315 / CP-9020038), with its maximum combined +12 Volt continuous current rating of 54 Amps and with two (6+2)-pin PCI Express supplementary power connectors, is way more than sufficient to power your system configuration with a single Radeon HD 7850 graphics card.
The number of PCI Express supplementary power connectors may become somewhat of a limitation depending on the number and model graphics card being used in the future.