If the main concern is for cooling, no. Most well designed mid towers are more than adequate for cooling with the proper components. Full towers are best for those that need the extra room for more components; i.e. drives. The mid tower case in my sig has never had a heat issue with 2 GTX 570s. I have a 200mm front, 140mm side, and 120mm rear fans with filtered/vented top.
I think maybe I'll just go with the mid tower then!
Hey by any chance do you play Battlefield 3? Just asking, because that's my most demanding game I own, and that's why I'm upgrading to a new desktop pc. I really like your setup! It's almost identical to what I have been looking at!