You might just manage the lowest possible settings on the laptop. I imagine the desktop should manage low. Probably high/very high if you get a HD 7750 with that desktop like Deemo13 suggested.
EDIT: I will just point out, those APU's might surprise you
I have one in my laptop and I can play Fallout 3/Oblivion etc. on the lowest possible settings. I wouldn't call the framerates high but for a single player game like that, it doesn't get annoying. Definitely playable.