I work mainly in 2D using Flash and comping in After Effects. I currently have a GTX 260, but was wondering if there is anything out there that would significantly boost any 2D performance? I do zero 3D work so that is a non issue for me. Are the Nvidia Quadro lines worth taking a look at? Should I stick with what I have?
If you are just using 2D animations, and not 3D I would just stick with what you have. The Quadro line is very expensive and is mainly for graphic/processor intense programs. If you absolutely wanted to upgrade, you could pick up a NVIDIA GeForce 550ti at newegg for $99 after rebate. That would give you much more processor power than your current.
P.S: I would upgrade because you OpenGL version is only 2.1. The 550ti is version 4.1. It also supports DirectX 11. After Effects' minimum requirements are OpenGL 2.0 which you match, but for future versions they may need a more up-to-date version.