Just from my personal experience, I set a basic starting point in the global section of the control panel, Then I customize the rest in-game. I rarely like auto-detected settings so I do everything in-game manually, that way I can tailor quality vs performance a little at a time, until I get 60 FPS and the best image possible on my rig. Lastly, by 33-60 fps, do you mean vsync? if so, by disabling it you may get some tearing, if you don't get tearing after disabling it, I would leave it off. Just my $.02.