you want it pointing so it's blowing air at an exhaust fan, most likely the rear fan. although you should be able to point it up as well, although i have no experience with your specific cooler.
Ok, either works but which would be more effective in your opinion?
Just so I'm clear with what your saying here. My cooler has two fans supplied with it, should one of those fans be right next to the exhaust fan? Or should one of the heatsink towers separate them?
Exhaust fan > 1st cooler fan > tower > 2nd cooler fan > tower.
Exhaust fan > tower > 1st cooler fan > tower > 2nd cooler fan.
Let me know if that made sense.
EDIT: Is anyone else getting all these 404 errors??