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Mouse and Keyboard unresponsive until 3rd boot attempt

Hello, I am not the most experienced with this kind of thing and I can't work this out. After being inactive for 6 hours (maybe less I haven't tested) On starting my computer the USB keyboard and mouse are completely unresponsive, cannot enter bios no response in windows 7. The second boot is the same. If I disconnect and reconnect once windows is running I get the device is not recognized. Sometimes Windows tries to load the driver and fails (even though I have reinstalled the driver several times). After the third fourth or sometimes fifth reboot, everything works normally: bios, windows no problems. Cannot make heads or tails of this. Windows 7 Ultimate, Gigabyte s-series motherboard, intel dual core processor, wireless laser mouse 6000. Anyone have any ideas? Thanks
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