Although people tend to blame the video card, without knowing better, it's most likely another defect asus motherboard.
Also: check all these settings...in the power profiles...it may help, but in the end, probably go for another ...manufacturer motherboard. Intel or Gigabyte is a better choice.
Although blaming the video card is easy, I will bet $1, it's a defect motherboard
One thing is to make sure that the priority of the game is highest; there maybe other processes running that have priority over the game.
Including for instance security programs and antivirus. The latest of which have gaming modes.
If there is not a gaming mode on the security try turning it OFF. Now test it with the security turned off. Multiple mismatched security programs can cause conflicts.
“Free” security downloaded from the internet can cause lots of problems…
Another good thing is to eliminate as many unused / junk / UN-needed applications.
Try to get rid of resource hog, un needed / unnecessary applications.
turn off the screen saver
Go into the power profiles,
set standby, hibernate and sleep to OFF
leave the monitor standby ON, that's OK (maybe not, try OFF)
Set the Hard Drive standby to NEVER
Set system Performance to MAXIMUM, not "quiet mode."
Open the bios set up and make sure "cool and quiet" is OFF. (AMD)
There may be a performance setting in the bios setup you have...make sure it's cranked up to max.
in the bios, see that the allocation for video, if available, is maxed.
Now open the hardware manager profiles...
click system properties
click device manager
double click on mice and other pointing devices
right click on HID compliant mouse
left click on properties
click on the power management tab
UN-check the box that says: "allow the computer to turn off this device to save power." (there is now NO check mark in this box)
Now repeat this procedure for all mice, monitors, keyboards, and ALL USB ports on the device manager list.
You must open ALL the devices one at a time, as above, and turn off the power saver, for each device.