I'm in the process of designing a new computer, with the main intent to process and validate designs through simulation, using ESI Quikcast . Large files will also be used in Rhino, around 1Gb in size.
The build will most likely happen in a couple months, approx. March 2013.
The purpose of the build is to reduce simulation times, as well as increase load times of Rhino models.
Budget is 2500-5000 for CPU, RAM, MB, Video Card (and possibly GPU, though not sure if there is GPU support for the ESI software at the moment)