Could be one of several things, like an IRQ conflict. Is DMA enabled on the drive in question? If not, you might find this <A HREF="http://forumz.tomshardware.com/hardware/modules.php?name=Forums&file=viewtopic&p=31905#31905" target="_new">post</A> interesting.
You may need to list some system specifications if checking this area doesn't fix the problem.
Toejam31
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