As long as the Motherboard has PCI-E (which is does) and you have enough space in the case bundled with a good PSU with all the required connections then it should be fine. It would be nice if you could list your specifications to see if it would be viable; it's hard to judge just from knowing the motherboard.
OS: Win 7 64bit
Processor: Intel Q8200 2.4GHz
GPU: Geforce GT120 1GB DDR2
This is my son's computer and finds the games he plays are a bit hit and mis graphically. ie, chivalry medeval warfare