If you want my opinion, for a card that powerful I would save the money and go with one at stock clocks. OCing your GPU will usually put more stress on it and make it die quicker. With a card like the 680, that card will be good enough to run games for as long as that card will keep working.
MSI cards all ship with their afterburner software (it's really cool, I use it on my 7770) that you can use to OC, you shouldn't have that hard of a time matching to clocks on the lighting but doing so will validate your warranty.