make sure the mb bios is up to date a lot of mb have bios patches and new cpu code. check that if your using an ssd the drive firmware is up to date. be care full of flash updating an ssd some of them will wipe the drive clean of all your data.
run cpu-z check that the ram speed and timing are fine. most time people forget to turn on xmp profile in ram. if your running an asus bios make sure your running stock speed not over clock. when you run over clock from the bios main page it can change the ram to bus timing from 1:1` to !:5 and cause issues. with cpu-z check that the mb loaded the ram speed right by reading the spd info. also check that your ram is on the mb qal list. run hardware monitor check the temps and voltages of your system. see if under hard load the power supply is holding and not rippling out.
Thanks, who knew that the motherboard driver CD didn't include BIOS updates.