I know that with Nvidia cards the Geforce cards are geared towards gamers, while the Quadro cards are targeted towards business and CAD applications. While they are sometimes similar from a HW perspective (besides amount of RAM), it is the firmware and drivers that often give the Quadro cards an edge in CAD performance. AMD cards offer the Radeon and FirePro series in a similar manner. Are we certain that the software you plan to use will support the Radeon series out-of-box? Tried and tested methods to make a Geforce GPU work similarly to a Quadro exist; you may want to look into workarounds for AMD. I can strongly reccommend a PSU upgrade, and an upgrade in your cooling. Sometimes a small financial investment at the onset will save you from expense and headache in the long run.