HELP! Serious problems with PC build

OK i'm having serious issues with my newest build. I am using a gigabyte 990fxA-ud3 motherboard with a water cooled loop through my CPU and video cards, AMD FX-8320 Vishera 3.5GHz (4.0GHz Turbo) Socket AM3+ 125W Eight-Core CPU. I have two HIS ATI 7850s, i'm using windows 7 on a 120gb kingston SSD, and 16 GB of ram(1866). My wireless mouse will not work, it won't install USB Devices(some of them will) I have two video cards and I want to crossfire them, but If I install new drivers or catalyst, when I restart it freezes, and I have to use system restore to get it to boot back up. And I also can't get any sound off from my optical audio output. I am completely at a loss, I have no clue what to try. I've put a lot of money and effort into this build, and I would like to get it running properly so I can play my games. Can someone out there help me? I am so frustrated!!!
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