you CAN set different resolutions on different monitors, you have been able to do so for a long time. i did this on an 8800gts for christ sake. although i wasnt aware the 660 could do 4 monitors. if you can you would probably need active display port adaptor, or adp monitor. i would look into that b4 you buy. and 2500x1600 is pushing it to game on that card, depending on the game and settings you may need to lower the res to 1080p to get good fps.