I think it could be a problem, since Zip drives are not DMA compatable to the best of my knowlege, and I don't think a controller can do both DAM and PIO modes at the same time!
I had the same thought and then I e-mailed Iomega and they said that the Zip should have no problems in DMA mode. I tried enabling DMA on the Zip and it works. Whaddaya know.
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