What is the main purpose for this PC?
If it is for gaming, that is one thing.
If it is for app performance, like rendering/editing, that is another.
Obviously, you have a high budget, but I advise you to save half of it.
For gaming:
1. A 46" TV is still only 1080P(1920 x 1080)
You will get very good graphics performance out of a GTX680.
But, really, the added 5% performance over a good GTX 670 may not be worth the price premium.
There is little advantage to 4gb compared to 2gb.
Read this:
http://www.pugetsystems.com/labs/articles/Video-Card-Performance-2GB-vs-4GB-Memory-154
2. From a cpu point of view, a 3570K with a mild OC to 4.3 is as good as it gets for gaming. Any Z77 based motherboard will do. No need for a enthusiast motherboard which is intended for record seeking competitive overclockers or professional gamers.
3. I do not advise the use of all on one liquid coolers in anything other than a small form factor case. They are expensive, noisy, and less reliable. In a decent case, they cool no better than a good air cooler. Something like acm hyper212 will do the job. If you want the best, look at noctua NH-D14 or phanteks.
4. With your budget, I suggest a 240gb ssd. It will hold the os and a bunch of games. The best is currently the samsung 840 pro.
5. No game, by itself uses more than 2-3gb. But, ram is cheap, and I suggest a 16gb kit of 2 x 8gb.
DDR3 1600 ram is all you need. Intel cpu's have a very good memory controller, and you will get negligible real performance improvement or fps from faster ram. 1-2% perhaps. Read this:
http://www.anandtech.com/show/4503/sandy-bridge-memory-scaling-choosing-the-best-ddr3
6. I suggest a quality psu of perhaps 750W from Seasonic. That will handle any single graphics card you might buy.
If you will mainly be running cpu bound multi threaded apps then do spend extra on the cpu.
The best would be a 3930K and a socket 2011 motherboard.
More reasonably, a 3770K and any Z77 based motherboard.
If your use is for 64 bit enabled apps like photoshop, then added ram is good, and 32gb might be warranted.
You will need windows 7 or 8 pro to access >16gb.
Find a case you love, and spend what you need to on it.
You will look at it every day.
If the case holds your motherboard and parts, and has two 120mm intake fans or equivalent, it will do the job.