start with one video card and one dimm ram. if you get a asus splash screen then it posting. if not post screen check to see if there any fault led on. on some of the newer mb you may need a bios update for the newer cpu and gpu. look at the mb ser# the end of it will have the bios rev #. the last bios is 1502. your mb like my sabertooth has a usb flashback port..just need a usb stick to flash the bios. one thing that can happen is the mb is shorted to the case if you forget the mb standoffs. also check that you have the 4/8 pin pci power plug connected. some mb it a 4 pin molex connector.without it the pci bus wont have the voltage to turn on the gpus.