I assume your asking about a 660ti vs anything above. If you use hefty amounts of antialiasing, yes, it cripples the card. Fortunetly it doesn't have too high an impact unless you stack on stupid amounts of it, say 8x MSAA, framerate takes a nosedive and theres very little gain in visual clarity gained. Other than that, not really.
Its not like you need more than 4x anyway.