I'm using a Crucial M4 in my desktop (HTPC) if that answers your question!
And it works flawlessly, no issues
Edit: SSD's both work great in laptops and desktops. The reason you might be asking is because HDD's are normally 3.5" whereas SSD's normally come in 2.5" size. Don't let the smaller size fool you - laptops and desktops (modern ones) both use the exact same SATA and SATA POWER cables.