Very simple... it is just a principle of physics.
Air is made of molecules that have a relative large distance inbetween. Now if you have only a fan blowing out you remove more molecules of air then there get inside the case through small holes... you create something called underpressure or vacuum. This is bad for both your fans (because the air is going to be more difficult to remove from inside your case) and the cooling because there are less molecules to cool the heatsinks.
Now if you got the reverse, more air comming in then going out you get overpressure... this is especially bad for the fans and helps creating dust because the particles of dust can stand still inside the case.
If you got an equal airflow comming in and out the air will continuisly flow and dust will be harder to form.
As for cleaning your components from dust... only the heatsinks make real sense to get cleaned. The rest of your hardware can survive dust with no problems.
My dual-PSU PC is so powerfull that the neighbourhood dims when I turn it on