I keep my notebook on most of the time. I just close the lid and it goes to sleep or hibernation. Or stand by.
You might want to restart every once in a while to clean the cobwebs out. Clean out your cache, cookies, run scan disk and some maintainance programs, virus scans, spybot, etc.
Maybe even do a cold boot once in a while. Take it out to dinner or Starbucks every once in a while. Feed it.
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